The role of SHBG and LPL gene polymorphism in the development of age-related hypogonadism in overweight men: Literature review

Abstract

Testosterone is the main male hormone responsible for the formation and maintenance of male sex characteristics and the sexual performance of men. With age testosterone levels decrease which is a natural physiological process. But the timing of age-related hypogonadism progress has individual differences. Physiological processes occurring in the body of an aging man are due to genetic, population and individual features of genes and their mutations leading to genetic polymorphism. Gene polymorphism is represented mainly by single nucleotide substitutions that are SNP (single nucleotide polymorphism). Genes SHBG and LPL are important links in the synthesis and transport of testosterone in male body as well as in the development of androgen deficiency. This review discusses the role of polymorphic variants of SHBG and LPL genes in the early development of age-related hypogonadism in overweight men.

Keywords

• age-related hypogonadism in men
• obesity
• polymorphism of SHBG and LPL genes
• overweight
• erectile dysfunction.