Decarboxylation of 2-keto fatty acids by brain

W. Ewart Davies; Amiya K. Hajra; Surendra S. Parmar; Norman S. Radin; James F. Mead

Journal of Lipid Research (Mar 1966)

Decarboxylation of 2-keto fatty acids by brain

W. Ewart Davies,
Amiya K. Hajra,
Surendra S. Parmar,
Norman S. Radin,
James F. Mead

Affiliations

W. Ewart Davies: Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan; Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California
Amiya K. Hajra: Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan; Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California
Surendra S. Parmar: Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan; Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California
Norman S. Radin: Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan; Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California
James F. Mead: Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan; Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, Center for the Health Sciences, University of California, Los Angeles, California

Journal volume & issue: Vol. 7, no. 2
pp. 270 – 276

Abstract

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An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid. Washing the enzyme powder with ethylenediaminetetraacetate and other chelating agents destroyed the activity. Further properties of the enzyme system are described. It is believed that this enzyme system accounts in part for the 1-carbon degradation route for brain fatty acids.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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Abstract

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