Biotechnological method of the synthesis of new ribavirin structural analogs.

Abstract

Modern effective biotechnological method of the synthesis of new analogues of 1-β-D-ribifuranozyl-1,2,4- triazole-3-carboxamide (ribavirin) from 3-amino-1,2,4-triazole was developed. Gene-engineering enzymes purine- and, thymidine phosphorylasis were used for biothecnological method of the synthesis ribavirin analogs.

Keywords

• модифицированные нуклеозиды, рибавирин, нуклеозидфосфорилазы, реакция трансгликозилирования.