Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis
Yue Cao,
Jinyao Chen,
Qian Bian,
Junyu Ning,
Ling Yong,
Tong Ou,
Yan Song,
Sheng Wei
Affiliations
Yue Cao
Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, China
Jinyao Chen
Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University, Yihuan Road, Chengdu 610041, China
Qian Bian
Institute of Toxicology and Risk Assessment, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road, Nanjing 210009, China
Junyu Ning
Institute of Toxicology, Beijing Center for Disease Prevention and Control, Hepingli Middle Street, Beijing 100013, China
Ling Yong
Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, China
Tong Ou
Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, China
Yan Song
Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, China
Sheng Wei
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road, Wuhan 430030, China
Background: Recent studies have raised concerns about genotoxic effects associated with titanium dioxide nanoparticles (TiO2 NPs), which are commonly used. This meta-analysis aims to investigate the potential genotoxicity of TiO2 NPs and explore influencing factors. Methods: This study systematically searched Chinese and English literature. The literature underwent quality evaluation, including reliability evaluation using the toxicological data reliability assessment method and relevance evaluation using routine evaluation forms. Meta-analysis and subgroup analyses were performed using R software, with the standardized mean difference (SMD) as the combined effect value. Results: A total of 26 studies met the inclusion criteria and passed the quality assessment. Meta-analysis results indicated that the SMD for each genotoxic endpoint was greater than 0. This finding implies a significant association between TiO2 NP treatment and DNA damage and chromosome damage both in vivo and in vitro and gene mutation in vitro. Subgroup analysis revealed that short-term exposure to TiO2 NPs increased DNA damage. Rats and cancer cells exhibited heightened susceptibility to DNA damage triggered by TiO2 NPs (p 2 NPs could induce genotoxicity, including DNA damage, chromosomal damage, and in vitro gene mutations. The mechanism of DNA damage response plays a key role in the genotoxicity induced by TiO2 NPs.
