Nature Communications (Jan 2019)

LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation

  • Valentina Profumo,
  • Barbara Forte,
  • Stefano Percio,
  • Federica Rotundo,
  • Valentina Doldi,
  • Elena Ferrari,
  • Nicola Fenderico,
  • Matteo Dugo,
  • Dario Romagnoli,
  • Matteo Benelli,
  • Riccardo Valdagni,
  • Diletta Dolfini,
  • Nadia Zaffaroni,
  • Paolo Gandellini

DOI
https://doi.org/10.1038/s41467-018-08153-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

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miR-205 is known to have context-dependent tumor suppressive or oncogenic roles. Here, the authors report the host gene of miR-205, MIR205HG as a nuclear lincRNA that maintains the basal identity of prostate cell and prevents luminal cell differentiation via the repression of interferon responsive genes.