Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Abstract

Highlights 1. Gene transcript profiles in the elderly AML patients are different from those in young patients. 2. Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients. 3. GEO and GSEA analyses demonstrate the genes of cancer pathway and mitogen activated protein kinase (MAPK) pathway, involved in natural immunity and metabolism, are largely down-regulated in elderly patients. 4. ATF4 is a biomarker indicating different therapeutic strategies for elderly patients.

Keywords

• Acute myeloid leukemia
• Platelet RNA sequencing
• Mitogen activated protein kinase
• Activating transcription factor 4