International Journal of Nanomedicine (Dec 2020)
Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing
Abstract
Que Bai,1,* Kai Han,1,* Kai Dong,1 Caiyun Zheng,1 Yanni Zhang,1 Qianfa Long,2 Tingli Lu1 1School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, People’s Republic of China; 2Mini-Invasive Neurosurgery and Translational Medical Center, Xi’an Central Hospital, Xi’an Jiaotong University, Xi’an 710003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qianfa Long; Tingli Lu Tel +86 029-88460332Email [email protected]; [email protected]: Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments of nanoparticles/hydrogels and nanotechnology used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. These nanoparticles/hydrogels promote diabetic wound healing by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) and non-bioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favored by researchers. In addition, nanoparticles/hydrogels can be combined with some technology (including PTT, LBL self-assembly technique and 3D-printing technology) to treat diabetic wound repair. By reviewing the recent literatures, we also proposed new strategies for improving multifunctional treatment of diabetic wounds in the future.Keywords: hydrogels, nanoparticles, nanotechnology, diabetic wound healing
