Nature Communications (Oct 2017)
Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers
Abstract
Store-operated calcium entry (SOCE) is elicited by the interaction of oligomerized STIM1 with plasma membrane Orai channels. Here, the authors show that this process is regulated by calmodulin, which binds STIM1 and disassembles the STIM1-Orai1 complex and STIM1 oligomers.