Generation of a human iPSC line (CIBi013-A) from a patient with young-onset Parkinson’s disease carrying a novel homozygous PARK7 (DJ-1) mutation

Lingfei Li; Xiaoli Si; Meng Lei; Jiayin Yang; Jie Ruan; Huifang Liu; Feifan Huang; Xuanxiang Jin; Keyue Xie; Hui Yang; Xiaoguang Lei; Yao Liu

Stem Cell Research (Feb 2023)

Generation of a human iPSC line (CIBi013-A) from a patient with young-onset Parkinson’s disease carrying a novel homozygous PARK7 (DJ-1) mutation

Lingfei Li,
Xiaoli Si,
Meng Lei,
Jiayin Yang,
Jie Ruan,
Huifang Liu,
Feifan Huang,
Xuanxiang Jin,
Keyue Xie,
Hui Yang,
Xiaoguang Lei,
Yao Liu

Affiliations

Lingfei Li: Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
Xiaoli Si: Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China
Meng Lei: Department of Neurology, The Third People's Hospital of Henan Province, Zhengzhou 450000, China
Jiayin Yang: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd, Shenzhen 518101, China
Jie Ruan: Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
Huifang Liu: Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong
Feifan Huang: The 1st School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
Xuanxiang Jin: The 1st School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
Keyue Xie: Department of Anesthesiology and Pain, The Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, China
Hui Yang: Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
Xiaoguang Lei: Department of Neurology, First Affiliated Hospital of Kunming Medical University, No.1 School of Clinical Medicine, Kunming Medical University, Kunming 650500, China; Corresponding authors.
Yao Liu: School of Rehabilitation, Kunming Medical University, Kunming 650500, China; Corresponding authors.

Journal volume & issue: Vol. 66
p. 102983

Abstract

Read online

Mutations in PARK7 and the resulting alterations in its production protein (DJ-1) are tightly associated with Parkinson’s disease. We generated a human induced pluripotent stem cell (iPSC) line (CIBi013-A) from a patient with young-onset Parkinson’s disease (YOPD) who carried a novel homozygous PARK7 (DJ-1) mutation (chr1:8037723, c.334C>G). The generated iPSCs will be used for investigating phenotype and underlying molecular mechanisms in patient-derived cells.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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