PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

Xin Wang; Youn-Sang Jung; Sohee Jun; Sunhye Lee; Wenqi Wang; Andrea Schneider; Young Sun Oh; Steven H. Lin; Bum-Joon Park; Junjie Chen; Khandan Keyomarsi; Jae-Il Park

doi:10.1038/ncomms10633

Nature Communications (Feb 2016)

PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

Xin Wang,
Youn-Sang Jung,
Sohee Jun,
Sunhye Lee,
Wenqi Wang,
Andrea Schneider,
Young Sun Oh,
Steven H. Lin,
Bum-Joon Park,
Junjie Chen,
Khandan Keyomarsi,
Jae-Il Park

Affiliations

Xin Wang: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Youn-Sang Jung: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Sohee Jun: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Sunhye Lee: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Wenqi Wang: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Andrea Schneider: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Young Sun Oh: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Steven H. Lin: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Bum-Joon Park: Department of Molecular Biology, Pusan National University
Junjie Chen: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Khandan Keyomarsi: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA
Jae-Il Park: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Z6.6034, Unit 1052, Houston, Texas 77030, USA

DOI: https://doi.org/10.1038/ncomms10633
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Stem cells are found in many tumour types and are thought to be partially responsible for cell survival following therapy. Here, the authors show that PCNA-associated factor, PAF, contributes to stemness in breast cancer cells and pharmacological targeting of PAF reduces mammosphere formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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