Nature Communications (May 2018)

Interpretable dimensionality reduction of single cell transcriptome data with deep generative models

  • Jiarui Ding,
  • Anne Condon,
  • Sohrab P. Shah

DOI
https://doi.org/10.1038/s41467-018-04368-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Although single-cell transcriptome data are increasingly available, their interpretation remains a challenge. Here, the authors present a dimensionality reduction approach that preserves both the local and global neighbourhood structures in the data thus enhancing its interpretability.