Nature Communications (Aug 2017)
MHC matching improves engraftment of iPSC-derived neurons in non-human primates
- Asuka Morizane,
- Tetsuhiro Kikuchi,
- Takuya Hayashi,
- Hiroshi Mizuma,
- Sayuki Takara,
- Hisashi Doi,
- Aya Mawatari,
- Matthew F. Glasser,
- Takashi Shiina,
- Hirohito Ishigaki,
- Yasushi Itoh,
- Keisuke Okita,
- Emi Yamasaki,
- Daisuke Doi,
- Hirotaka Onoe,
- Kazumasa Ogasawara,
- Shinya Yamanaka,
- Jun Takahashi
Affiliations
- Asuka Morizane
- Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
- Tetsuhiro Kikuchi
- Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
- Takuya Hayashi
- RIKEN Center for Life Science Technologies (CLST)
- Hiroshi Mizuma
- RIKEN Center for Life Science Technologies (CLST)
- Sayuki Takara
- RIKEN Center for Life Science Technologies (CLST)
- Hisashi Doi
- RIKEN Center for Life Science Technologies (CLST)
- Aya Mawatari
- RIKEN Center for Life Science Technologies (CLST)
- Matthew F. Glasser
- Department of Neuroscience, Washington University School of Medicine
- Takashi Shiina
- Department of Molecular Life Science, Tokai University, School of Medicine
- Hirohito Ishigaki
- Department of Pathology, Shiga University of Medical Science
- Yasushi Itoh
- Department of Pathology, Shiga University of Medical Science
- Keisuke Okita
- Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University
- Emi Yamasaki
- Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
- Daisuke Doi
- Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
- Hirotaka Onoe
- RIKEN Center for Life Science Technologies (CLST)
- Kazumasa Ogasawara
- Department of Pathology, Shiga University of Medical Science
- Shinya Yamanaka
- Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University
- Jun Takahashi
- Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-017-00926-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.
