Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome

Alain Chebly; Claudia Djambas Khayat; Tony Yammine; Rima Korban; Warde Semaan; Jessica Bou Zeid; Chantal Farra

Leukemia Research Reports (Jan 2021)

Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome

Alain Chebly,
Claudia Djambas Khayat,
Tony Yammine,
Rima Korban,
Warde Semaan,
Jessica Bou Zeid,
Chantal Farra

Affiliations

Alain Chebly: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Claudia Djambas Khayat: Department of Pediatrics, Hotel Dieu de France Medical Center, Beirut, Lebanon
Tony Yammine: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Rima Korban: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Warde Semaan: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Jessica Bou Zeid: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Chantal Farra: Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon; Department of Genetics, Hotel Dieu de France Medical Center, Beirut, Lebanon; Corresponding author at: Saint Joseph University, Damascus street, B.P. 17-5208, Mar Mikhaël, Beirut, 1104 2020 Beirut, Lebanon.

Journal volume & issue: Vol. 16
p. 100277

Abstract

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Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6. The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML-MLL-SEPT6 cases.

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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