Shortness of Breath on Day 1 After Surgery Alerting the Presence of Early Respiratory Complications After Surgery in Lung Cancer Patients

Abstract

Qingsong Yu,1 Hongfan Yu,1 Wei Xu,1 Yang Pu,1 Yuxian Nie,2 Wei Dai,3 Xing Wei,3 Xin Shelley Wang,4 Charles S Cleeland,4 Qiang Li,3 Qiuling Shi1,2,5 1School of Public Health and Management, Chongqing Medical University, Chongqing, People’s Republic of China; 2State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of China; 4Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 5Center for Cancer Prevention Research, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Qiuling Shi, School of Public Health and Management, Chongqing Medical University, No. 1, Medical School Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Tel [phone], Fax [phone], Email [email protected]: Patient-reported outcome (PRO)-based symptom assessment with a threshold can facilitate the early alert of adverse events. The purpose of this study was to determine whether shortness of breath (SOB) on postoperative day 1 (POD1) can inform postoperative pulmonary complications (PPCs) for patients after lung cancer (LC) surgery.Methods: Data were extracted from a prospective cohort study of patients with LC surgery. Symptoms were assessed by the MD Anderson Symptom Inventory-lung cancer module (MDASI-LC) before and daily after surgery. Types and grades of complications during hospitalization were recorded. SOB and other symptoms were tested for a possible association with PPCs by logistic regression models. Optimal cutpoints of SOB were derived, using the presence of PPCs as an anchor.Results: Among 401 patients with complete POD1 MDASI-LC and records on postoperative complications, 46 (11.5%) patients reported Clavien–Dindo grade II-IV PPCs. Logistic regression revealed that higher SOB score on POD1 (odds ratio [OR]=1.13, 95% CI=1.01– 1.27), male (OR=2.86, 95% CI=1.32– 6.23), open surgery (OR=3.03, 95% CI=1.49– 6.14), and lower forced expiratory volume in one second (OR=1.78, 95% CI=1.66– 2.96) were significantly associated with PPCs. The optimal cutpoint was 6 (on a 0– 10 scale) for SOB. Patients reporting SOB < 6 on POD1 had shorter postoperative length of stay than those reporting 6 or greater SOB (median, 6 vs 7, P =0.007).Conclusion: SOB on POD1 can inform the onset of PPCs in patients after lung cancer surgery. PRO-based symptom assessment with a clinically meaningful threshold could alert clinicians for the early management of PPCs.Keywords: lung cancer, surgery, postoperative pulmonary complications, patient-reported outcomes, shortness of breath

Keywords

• lung cancer
• surgery
• postoperative pulmonary complications
• patient-reported outcomes
• shortness of breath