A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans

Usha K. Nivarthi; Jesica Swanstrom; Matthew J. Delacruz; Bhumi Patel; Anna P. Durbin; Steve S. Whitehead; Beth D. Kirkpatrick; Kristen K. Pierce; Sean A. Diehl; Leah Katzelnick; Ralph S. Baric; Aravinda M. de Silva

doi:10.1038/s41467-021-21384-0

Nature Communications (Feb 2021)

A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans

Usha K. Nivarthi,
Jesica Swanstrom,
Matthew J. Delacruz,
Bhumi Patel,
Anna P. Durbin,
Steve S. Whitehead,
Beth D. Kirkpatrick,
Kristen K. Pierce,
Sean A. Diehl,
Leah Katzelnick,
Ralph S. Baric,
Aravinda M. de Silva

Affiliations

Usha K. Nivarthi: Department of Microbiology and Immunology, University of North Carolina School of Medicine
Jesica Swanstrom: Department of Epidemiology, University of North Carolina Gillings School of Public Health
Matthew J. Delacruz: Department of Microbiology and Immunology, University of North Carolina School of Medicine
Bhumi Patel: Department of Microbiology and Immunology, University of North Carolina School of Medicine
Anna P. Durbin: Johns Hopkins Bloomberg School of Public Health, Department of International Health
Steve S. Whitehead: Laboratory of Infectious Diseases, NIAID, National Institutes of Health
Beth D. Kirkpatrick: Vaccine Testing Center, Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine
Kristen K. Pierce: Vaccine Testing Center, Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine
Sean A. Diehl: Vaccine Testing Center, Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine
Leah Katzelnick: Laboratory of infectious Diseases, NIAID
Ralph S. Baric: Department of Microbiology and Immunology, University of North Carolina School of Medicine
Aravinda M. de Silva: Department of Microbiology and Immunology, University of North Carolina School of Medicine

DOI: https://doi.org/10.1038/s41467-021-21384-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Multivalent vaccines that confer protection to multiple serotypes of Dengue virus have been established. Here the authors examine the presence of vaccine induced multivalent antibodies and how these link to protection in a human challenge model of Dengue virus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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