Emerging Infectious Diseases (Nov 2023)

Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

  • Qiaozhen Cui,
  • Chen Wang,
  • Qichen Wang,
  • Juanxiu Qin,
  • Min Li,
  • Baixing Ding,
  • Zhen Shen

DOI
https://doi.org/10.3201/eid2911.230830
Journal volume & issue
Vol. 29, no. 11
pp. 2398 – 2400

Abstract

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We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for blaSHV-12, leading to blaSHV-12 overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.