Recurrent nitrofurantoin-induced giant cell interstitial pneumonia: Case report and literature review

Abstract

Giant cell interstitial pneumonia (GIP) is a rare form of chronic interstitial pneumonia typically associated with hard metal exposure. Only two cases of GIP induced by nitrofurantoin have been reported in the medical literature. We are reporting a case of recurrent nitrofurantoin-induced GIP. Although extremely rare, GIP needs to be included in the differential diagnosis in patients with chronic nitrofurantoin use who present with respiratory illness.

Keywords

• Giant cells
• Nitrofurantoin
• Lung toxicity
• Interstitial pneumonia
• Metals