Data in Brief (Dec 2017)

Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes

  • Won-Mo Yang,
  • Kyung-Ho Min,
  • Se-Whan Park,
  • Wan Lee

Journal volume & issue
Vol. 15
pp. 800 – 804

Abstract

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Obesity and metabolic diseases are closely associated with insulin resistance. Obesity-induced miRNAs are also considered to be potential contributors to the development of insulin resistance and type 2 diabetes. Previously, the expression of miR-1271 was reported to be upregulated in the liver of diet-induced obese mice (Yang et al., 2016) [1]. In this data article, multiple in silico analysis predicted FOXO1 gene to be a direct target of miR-1271. Dual luciferase reporter gene analysis showed that miR-1271 suppressed FOXO1 expression by direct binding to 3′UTR. The overexpression of miR-1271 reduced the protein expression of FOXO1, thereby reducing the transcription of PEPCK, a downstream target of FOXO1. The data is related to a research article entitled 'MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells' (Yang et al., 2016) [1]. Keywords: MicroRNAs, miR-1271, FOXO1, Hepatocyte