Nature Communications (Apr 2020)

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

  • Sean M. Flynn,
  • Changchun Chen,
  • Murat Artan,
  • Stephen Barratt,
  • Alastair Crisp,
  • Geoffrey M. Nelson,
  • Sew-Yeu Peak-Chew,
  • Farida Begum,
  • Mark Skehel,
  • Mario de Bono

DOI
https://doi.org/10.1038/s41467-020-15872-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and longevity.