The role of intestinal disbiosis in the development of mitochondrial dysfunction and nonalcoholic fatty liver disease

Abstract

Taking into account the numerous metabolic functions of microflora, violation of its colonization resistance is considered as a trigger factor in the development of a number of different diseases. Thus, studies conducted in recent years demonstrate a significant relationship of dysbiotic intestinal microflora disorders with the pathogenesis of NAFLD, caused by damage to the mitochondria. It is proved that mitochondrial dysfunction plays a significant role not only in the development of SEX, which leads to membrane damage, necrosis and apoptosis of hepatocytes, but also to the progression of steatosis. Clinical signs of acute and chronic liver disease suggests that, regardless of their etiology, clinical manifestations, come to the fore phenomena are typical for mitochondrial dysfunction. The data presented in the article demonstrate the importance of dysbiotic changes in the development of mitochondrial dysfunction, the formation of steatosis in non-alcoholic fatty liver disease, with its subsequent transformation into steatohepatitis and progression to fibrosis and cirrhosis.

Keywords

• dysbiosis
• mitochondrial dysfunction
• liver
• nafld
• steatosis