Utility of Challenge Test in Immediate Hypersensitivity to Hydrocortisone Sodium Succinate

Abstract

Corticosteroid hypersensitivity is a complex phenomenon in which many factors interact, such as idiosyncrasy, intolerance or allergic reactions. The prevalence of immediate hypersensitivity reactions to corticosteroids is 0.2%-0.5%. Corticosteroids have major therapeutic implications; thus, when hypersensitivity is suspected, in-vitro and/or in-vivo testing can be performed to con rm diagnosis, being the drug challenge the gold standard. After de nitive diagnosis, cross-reactivity among the different corticosteroid groups should be considered, to choose wisely if corticosteroid therapy is still required. In Coopman classi cation, steroids belonging to groups A, B and D2 have high cross-reactivity, however, more studies are needed to determine the degree of cross-reaction among these drugs. This paper presents the case of a woman, in who hypersensitivity to hydrocortisone succinate was con rmed by drug challenge test.

Keywords

• corticoesteroides
• hipersensibilidad
• prueba de reto
• reactividad cruzada