Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

Amanda L. M. Bloom; Richard M. Jin; Jay Leipheimer; Jonathan E. Bard; Donald Yergeau; Elizabeth A. Wohlfert; John C. Panepinto

doi:10.1038/s41467-019-12907-x

Nature Communications (Oct 2019)

Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

Amanda L. M. Bloom,
Richard M. Jin,
Jay Leipheimer,
Jonathan E. Bard,
Donald Yergeau,
Elizabeth A. Wohlfert,
John C. Panepinto

Affiliations

Amanda L. M. Bloom: Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY
Richard M. Jin: Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY
Jay Leipheimer: Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY
Jonathan E. Bard: New York State Center of Excellence and Bioinformatics, University at Buffalo, SUNY
Donald Yergeau: New York State Center of Excellence and Bioinformatics, University at Buffalo, SUNY
Elizabeth A. Wohlfert: Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY
John C. Panepinto: Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY

DOI: https://doi.org/10.1038/s41467-019-12907-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wall glucans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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