Nature Communications (Oct 2019)

Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

  • Amanda L. M. Bloom,
  • Richard M. Jin,
  • Jay Leipheimer,
  • Jonathan E. Bard,
  • Donald Yergeau,
  • Elizabeth A. Wohlfert,
  • John C. Panepinto

DOI
https://doi.org/10.1038/s41467-019-12907-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wall glucans.