Infection and Drug Resistance (Jul 2020)

Prevalence of Common Nosocomial Infections and Evaluation of Antibiotic Resistance Patterns in Patients with Secondary Infections in Hamadan, Iran

  • Nouri F,
  • Karami P,
  • Zarei O,
  • Kosari F,
  • Alikhani MY,
  • Zandkarimi E,
  • Rezazadeh Zarandi E,
  • Taheri M

Journal volume & issue
Vol. Volume 13
pp. 2365 – 2374

Abstract

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Fatemeh Nouri,1 Pezhman Karami,2 Omid Zarei,3 Faezeh Kosari,3 Mohammad Yousef Alikhani,2 Eghbal Zandkarimi,4 Ebrahim Rezazadeh Zarandi,5 Mohammad Taheri2 1Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Medical Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 3Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran; 4Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran; 5Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, IranCorrespondence: Mohammad TaheriDepartment of Medical Microbiology, Hamadan University of Medical Sciences, Hamadan, IranTel +98-9124061190Fax +98-8134237100Email [email protected]: The prevalence of nosocomial infections in patients hospitalized to three hospitals of Shahid Beheshti, Farshchian, and Be’ saat in Hamadan was investigated for 2 years (2018 to 2020).Materials and Methods: The samples were cultured and characterized using morphological and diagnostic biochemical tests. The analysis of the frequency of the isolates and their antibiotic resistance were calculated using SPSS (version 22) at a significant level of P-value < 0.05.Results: Bacterial isolates were collected from the 1194 clinical specimens, of which 1394 were isolated from urine, 16 from CSF, and 588 from tracheal aspiration. Also, 654 (54.8%) isolates were obtained from females and 540 (45.2%) from males with the age range 15– 73 years (P> 0.05). The results showed that 22.1% were gram-positive and 77.9% were gram-negative. In our study, the frequency of Klebsiella pneumoniae bacteria was higher than in some studies, and this indicates the genetic changes and resistance of this bacterium to many antibiotics.Conclusion: To prevent further spread of resistance, increase the effectiveness of antibiotics and prevent multidrug resistance, it is essential to establish a precise schedule for the use of antibiotics and assess the resistance pattern periodically in each region based on the antibiotic resistance pattern.Keywords: nosocomial infections, UTI, trachea, CSF, antimicrobial resistance pattern

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