Journal of Intensive Care (Mar 2025)

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

  • Nobuaki Shime,
  • Taka-aki Nakada,
  • Tomoaki Yatabe,
  • Kazuma Yamakawa,
  • Yoshitaka Aoki,
  • Shigeaki Inoue,
  • Toshiaki Iba,
  • Hiroshi Ogura,
  • Yusuke Kawai,
  • Atsushi Kawaguchi,
  • Tatsuya Kawasaki,
  • Yutaka Kondo,
  • Masaaki Sakuraya,
  • Shunsuke Taito,
  • Kent Doi,
  • Hideki Hashimoto,
  • Yoshitaka Hara,
  • Tatsuma Fukuda,
  • Asako Matsushima,
  • Moritoki Egi,
  • Shigeki Kushimoto,
  • Takehiko Oami,
  • Kazuya Kikutani,
  • Yuki Kotani,
  • Gen Aikawa,
  • Makoto Aoki,
  • Masayuki Akatsuka,
  • Hideki Asai,
  • Toshikazu Abe,
  • Yu Amemiya,
  • Ryo Ishizawa,
  • Tadashi Ishihara,
  • Tadayoshi Ishimaru,
  • Yusuke Itosu,
  • Hiroyasu Inoue,
  • Hisashi Imahase,
  • Haruki Imura,
  • Naoya Iwasaki,
  • Noritaka Ushio,
  • Masatoshi Uchida,
  • Michiko Uchi,
  • Takeshi Umegaki,
  • Yutaka Umemura,
  • Akira Endo,
  • Marina Oi,
  • Akira Ouchi,
  • Itsuki Osawa,
  • Yoshiyasu Oshima,
  • Kohei Ota,
  • Takanori Ohno,
  • Yohei Okada,
  • Hiromu Okano,
  • Yoshihito Ogawa,
  • Masahiro Kashiura,
  • Daisuke Kasugai,
  • Ken-ichi Kano,
  • Ryo Kamidani,
  • Akira Kawauchi,
  • Sadatoshi Kawakami,
  • Daisuke Kawakami,
  • Yusuke Kawamura,
  • Kenji Kandori,
  • Yuki Kishihara,
  • Sho Kimura,
  • Kenji Kubo,
  • Tomoki Kuribara,
  • Hiroyuki Koami,
  • Shigeru Koba,
  • Takehito Sato,
  • Ren Sato,
  • Yusuke Sawada,
  • Haruka Shida,
  • Tadanaga Shimada,
  • Motohiro Shimizu,
  • Kazushige Shimizu,
  • Takuto Shiraishi,
  • Toru Shinkai,
  • Akihito Tampo,
  • Gaku Sugiura,
  • Kensuke Sugimoto,
  • Hiroshi Sugimoto,
  • Tomohiro Suhara,
  • Motohiro Sekino,
  • Kenji Sonota,
  • Mahoko Taito,
  • Nozomi Takahashi,
  • Jun Takeshita,
  • Chikashi Takeda,
  • Junko Tatsuno,
  • Aiko Tanaka,
  • Masanori Tani,
  • Atsushi Tanikawa,
  • Hao Chen,
  • Takumi Tsuchida,
  • Yusuke Tsutsumi,
  • Takefumi Tsunemitsu,
  • Ryo Deguchi,
  • Kenichi Tetsuhara,
  • Takero Terayama,
  • Yuki Togami,
  • Takaaki Totoki,
  • Yoshinori Tomoda,
  • Shunichiro Nakao,
  • Hiroki Nagasawa,
  • Yasuhisa Nakatani,
  • Nobuto Nakanishi,
  • Norihiro Nishioka,
  • Mitsuaki Nishikimi,
  • Satoko Noguchi,
  • Suguru Nonami,
  • Osamu Nomura,
  • Katsuhiko Hashimoto,
  • Junji Hatakeyama,
  • Yasutaka Hamai,
  • Mayu Hikone,
  • Ryo Hisamune,
  • Tomoya Hirose,
  • Ryota Fuke,
  • Ryo Fujii,
  • Naoki Fujie,
  • Jun Fujinaga,
  • Yoshihisa Fujinami,
  • Sho Fujiwara,
  • Hiraku Funakoshi,
  • Koichiro Homma,
  • Yuto Makino,
  • Hiroshi Matsuura,
  • Ayaka Matsuoka,
  • Tadashi Matsuoka,
  • Yosuke Matsumura,
  • Akito Mizuno,
  • Sohma Miyamoto,
  • Yukari Miyoshi,
  • Satoshi Murata,
  • Teppei Murata,
  • Hiromasa Yakushiji,
  • Shunsuke Yasuo,
  • Kohei Yamada,
  • Hiroyuki Yamada,
  • Ryo Yamamoto,
  • Ryohei Yamamoto,
  • Tetsuya Yumoto,
  • Yuji Yoshida,
  • Shodai Yoshihiro,
  • Satoshi Yoshimura,
  • Jumpei Yoshimura,
  • Hiroshi Yonekura,
  • Yuki Wakabayashi,
  • Takeshi Wada,
  • Shinichi Watanabe,
  • Atsuhiro Ijiri,
  • Kei Ugata,
  • Shuji Uda,
  • Ryuta Onodera,
  • Masaki Takahashi,
  • Satoshi Nakajima,
  • Junta Honda,
  • Tsuguhiro Matsumoto

DOI
https://doi.org/10.1186/s40560-025-00776-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 61

Abstract

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Abstract The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes. We aimed to create guidelines that are easy to understand and use for physicians who recognize sepsis and provide initial management, specialized physicians who take over the treatment, and multidisciplinary healthcare providers, including nurses, physical therapists, clinical engineers, and pharmacists. The J-SSCG 2024 covers the following nine areas: diagnosis of sepsis and source control, antimicrobial therapy, initial resuscitation, blood purification, disseminated intravascular coagulation, adjunctive therapy, post-intensive care syndrome, patient and family care, and pediatrics. In these areas, we extracted 78 important clinical issues. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members. As a result, 42 GRADE-based recommendations, 7 good practice statements, and 22 information-to-background questions were created as responses to clinical questions. We also described 12 future research questions.

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