Nature Communications (Jan 2017)
DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
- Soulafa Mamlouk,
- Liam Harold Childs,
- Daniela Aust,
- Daniel Heim,
- Friederike Melching,
- Cristiano Oliveira,
- Thomas Wolf,
- Pawel Durek,
- Dirk Schumacher,
- Hendrik Bläker,
- Moritz von Winterfeld,
- Bastian Gastl,
- Kerstin Möhr,
- Andrea Menne,
- Silke Zeugner,
- Torben Redmer,
- Dido Lenze,
- Sascha Tierling,
- Markus Möbs,
- Wilko Weichert,
- Gunnar Folprecht,
- Eric Blanc,
- Dieter Beule,
- Reinhold Schäfer,
- Markus Morkel,
- Frederick Klauschen,
- Ulf Leser,
- Christine Sers
Affiliations
- Soulafa Mamlouk
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Liam Harold Childs
- Knowledge Management in Bioinformatics, Humboldt University of Berlin
- Daniela Aust
- German Cancer Consortium (DKTK)
- Daniel Heim
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Friederike Melching
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Cristiano Oliveira
- Institute of Pathology, University of Heidelberg
- Thomas Wolf
- German Cancer Consortium (DKTK)
- Pawel Durek
- Experimental Rheumatology, German Rheumatism Research Centre
- Dirk Schumacher
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Hendrik Bläker
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Moritz von Winterfeld
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Bastian Gastl
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Kerstin Möhr
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Andrea Menne
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Silke Zeugner
- Institute for Pathology, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Torben Redmer
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Dido Lenze
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Sascha Tierling
- Department of Genetics/Epigenetics, FR8.3 Life Sciences, Saarland University
- Markus Möbs
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Wilko Weichert
- German Cancer Consortium (DKTK)
- Gunnar Folprecht
- University Hospital Carl Gustav Carus, University Cancer Center/Medical Dpt. I
- Eric Blanc
- Core Unit Bioinformatics, Berlin Institute of Health
- Dieter Beule
- Core Unit Bioinformatics, Berlin Institute of Health
- Reinhold Schäfer
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Markus Morkel
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Frederick Klauschen
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Ulf Leser
- Knowledge Management in Bioinformatics, Humboldt University of Berlin
- Christine Sers
- Institute of Pathology, Charité Universitätsmedizin Berlin
- DOI
- https://doi.org/10.1038/ncomms14093
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
The contribution of intra-tumour heterogeneity is increasingly associated with resistance to therapy. Here, the authors use genomic analyses to study heterogeneity in colorectal cancer and perform in-depth reconstruction of heterogeneity in one sample.
