Frontiers in Immunology (Sep 2024)

The role of cytokines in the pathogenesis of SAPHO syndrome

  • Yi Yang,
  • Yi Yang,
  • Qianzhu Chen,
  • Qianzhu Chen,
  • Weiyang Zhong,
  • Weiyang Zhong

DOI
https://doi.org/10.3389/fimmu.2024.1427784
Journal volume & issue
Vol. 15

Abstract

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SAPHO syndrome is a complex inflammatory disorder affecting the skin and bones, characterized by osteomyelitis, acne, and pustulosis. Cytokines play a pivotal role in the pathogenesis of SAPHO syndrome, especially in inflammatory responses and immune regulation. This article reviews the cytokines involved in the pathogenesis of SAPHO syndrome, such as tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6, IL-10, and transforming growth factor-β (TGF-β), and discusses their potential as intervention points for treatment. These findings elucidate the intricate immune regulatory network of SAPHO syndrome and provide a theoretical foundation for the development of new targeted therapeutic strategies.

Keywords