PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

Qian Chen; Muzaffer Ahmad Kassab; Françoise Dantzer; Xiaochun Yu

doi:10.1038/s41467-018-05588-5

Nature Communications (Aug 2018)

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

Qian Chen,
Muzaffer Ahmad Kassab,
Françoise Dantzer,
Xiaochun Yu

Affiliations

Qian Chen: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center
Muzaffer Ahmad Kassab: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center
Françoise Dantzer: UMR7242, Biotechnology and Cell Signaling, École Supérieure de Biotechnologie de Strasbourg, CNRS/Strasbourg University
Xiaochun Yu: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center

DOI: https://doi.org/10.1038/s41467-018-05588-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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PARP1 and PARP2 of the PARP family enzymes are involved in DNA damage response. Here the authors report PARP2 activation mechanisms and its role in the formation of branched poly(ADP-ribose) chains in response to DNA damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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