Integrative lipidomic features identify plasma lipid signatures in chronic urticaria

Jie Li; Jie Li; Jie Li; Jie Li; Liqiao Li; Liqiao Li; Liqiao Li; Liqiao Li; Runqiu Liu; Runqiu Liu; Runqiu Liu; Runqiu Liu; Lei Zhu; Lei Zhu; Lei Zhu; Lei Zhu; Bingjing Zhou; Bingjing Zhou; Bingjing Zhou; Bingjing Zhou; Yi Xiao; Yi Xiao; Yi Xiao; Yi Xiao; Guixue Hou; Liang Lin; Xiang Chen; Xiang Chen; Xiang Chen; Xiang Chen; Cong Peng; Cong Peng; Cong Peng; Cong Peng

doi:10.3389/fimmu.2022.933312

Frontiers in Immunology (Jul 2022)

Integrative lipidomic features identify plasma lipid signatures in chronic urticaria

Jie Li,
Jie Li,
Jie Li,
Jie Li,
Liqiao Li,
Liqiao Li,
Liqiao Li,
Liqiao Li,
Runqiu Liu,
Runqiu Liu,
Runqiu Liu,
Runqiu Liu,
Lei Zhu,
Lei Zhu,
Lei Zhu,
Lei Zhu,
Bingjing Zhou,
Bingjing Zhou,
Bingjing Zhou,
Bingjing Zhou,
Yi Xiao,
Yi Xiao,
Yi Xiao,
Yi Xiao,
Guixue Hou,
Liang Lin,
Xiang Chen,
Xiang Chen,
Xiang Chen,
Xiang Chen,
Cong Peng,
Cong Peng,
Cong Peng,
Cong Peng

Affiliations

Jie Li: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Jie Li: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Jie Li: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Jie Li: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Liqiao Li: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Liqiao Li: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Liqiao Li: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Liqiao Li: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Runqiu Liu: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Runqiu Liu: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Runqiu Liu: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Runqiu Liu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Lei Zhu: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Lei Zhu: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Lei Zhu: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Lei Zhu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Bingjing Zhou: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Bingjing Zhou: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Bingjing Zhou: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Bingjing Zhou: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yi Xiao: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Yi Xiao: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Yi Xiao: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Yi Xiao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Guixue Hou: BGI-Shenzhen, Shenzhen, Guangdong, China
Liang Lin: BGI-Shenzhen, Shenzhen, Guangdong, China
Xiang Chen: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Xiang Chen: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Xiang Chen: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Xiang Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Cong Peng: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Cong Peng: Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China
Cong Peng: Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China
Cong Peng: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fimmu.2022.933312
Journal volume & issue: Vol. 13

Abstract

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Chronic urticaria (CU) is a chronic inflammatory skin disease mainly mediated by mast cells. Lipids exert essential functions in biological processes; however, the role of lipids in CU remains unclear. Nontargeted lipidomics was performed to investigate the differential lipid profiles between CU patients and healthy control (HC) subjects. Functional validation studies were performed in vitro and in vivo including β-hexosaminidase release examination from mast cells and passive cutaneous anaphylaxis (PCA) mouse model. We detected dramatically altered glycerophospholipids in CU patients compared with HCs. Phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) were increased, while phosphatidylcholine (PC) was reduced in CU patients. The reduction in PC was related to a high weekly urticaria activity score (UAS7), while PS was positively associated with the dermatology life quality index (DLQI). We also identified the differential lipid profiles between chronic spontaneous urticaria (CSU), symptomatic dermographism (SD), and CSU coexist with SD. CU patients were classified into two subtypes (subtype 1 and subtype 2) based on consensus clustering of lipid profiling. Compared with patients in subtype 2, patients in subtype 1 had elevated levels of PC (18:0e/18:2) and PE (38:2), and lower urticaria control test (UCT) scores indicated worse clinical efficiency of secondary generation H1 antihistamines treatment. Importantly, we found that supplementation with PC could attenuate IgE-induced immune responses in mast cells. In general, We described the landscape of plasma lipid alterations in CU patients and provided novel insights into the role of PC in mast cells.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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