Evaluation of serum concentration Interleukins in Patients with Myocardial Infarction by ELISA Technique.

Abstract

To evaluate the serum concentrations of proinflammatory cytokines interleukin (IL-1, IL-6, IL-8, IL-18), tumour necrosis factor α (TNF-α), C-reactive protein (CRP), and anti-inflammatory cytokine interleukin 10 (IL-10) regulatory in patients with AMI, and to assess the correlation between anti-inflammatory and pro-inflammatory cytokines in AMI. Thirty patients (13 women and 17 men) with (AMI) enrolled in this study and 30 as control group (10 women and 20 men). There aged varied between 40-60 years old. In this study were measured serum levels of proinflammatory cytokines interleukin (IL-6, IL-1, IL-18, and IL-8), TNF-α, and anti-inflammatory cytokine interleukin 10 (IL-10) in both patient and in control groups by using ELISA technique. Serum levels of interleukine-6, IL-1α, IL-8, and IL-18, CRP, and TNF-α were significantly higher whereas serum IL-10 L level in AMI patients in compares with control group. This study shows a significantly increase in IL-1, IL-18,IL-6,andIL-18 and decrease in IL-10 in the circulation of AMI.

Keywords

• acute myocardial infarction
• interleukins
• and cytokines