Chalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides

Jianjian Liu; Mali Zhou; Rui Deng; Pengcheng Zheng; Yonggui Robin Chi

doi:10.1038/s41467-022-32428-4

Nature Communications (Aug 2022)

Chalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides

Jianjian Liu,
Mali Zhou,
Rui Deng,
Pengcheng Zheng,
Yonggui Robin Chi

Affiliations

Jianjian Liu: State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University
Mali Zhou: State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University
Rui Deng: State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University
Pengcheng Zheng: State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University
Yonggui Robin Chi: State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University

DOI: https://doi.org/10.1038/s41467-022-32428-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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Conformational isomerization of organic molecules can be guided by noncovalent interactions. Here, the authors report the synthesis of chiral sulfoxides catalyzed by N-heterocyclic carbenes; intramolecular chalcogen bonding interactions are key for conformational locking.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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