Nature Communications (Jun 2020)
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities
- Ravi S. Narayan,
- Piet Molenaar,
- Jian Teng,
- Fleur M. G. Cornelissen,
- Irene Roelofs,
- Renee Menezes,
- Rogier Dik,
- Tonny Lagerweij,
- Yoran Broersma,
- Naomi Petersen,
- Jhon Alexander Marin Soto,
- Eelke Brands,
- Philip van Kuiken,
- Maria C. Lecca,
- Kristiaan J. Lenos,
- Sjors G. J. G. In ‘t Veld,
- Wessel van Wieringen,
- Frederick F. Lang,
- Erik Sulman,
- Roel Verhaak,
- Brigitta G. Baumert,
- Lucas J. A. Stalpers,
- Louis Vermeulen,
- Colin Watts,
- David Bailey,
- Ben J. Slotman,
- Rogier Versteeg,
- David Noske,
- Peter Sminia,
- Bakhos A. Tannous,
- Tom Wurdinger,
- Jan Koster,
- Bart A. Westerman
Affiliations
- Ravi S. Narayan
- Department of Radiation Oncology, Amsterdam UMC, location VUMC, Cancer Center
- Piet Molenaar
- Department of Oncogenomics, Academic Medical Center
- Jian Teng
- Experimental Therapeutics and Molecular Imaging Lab, Neuroscience Center, Neuro-Oncology Unit, Massachusetts General Hospital and Harvard Medical School
- Fleur M. G. Cornelissen
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Irene Roelofs
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Renee Menezes
- Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute
- Rogier Dik
- Department of Radiation Oncology, Amsterdam UMC, location VUMC, Cancer Center
- Tonny Lagerweij
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Yoran Broersma
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Naomi Petersen
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Jhon Alexander Marin Soto
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Eelke Brands
- Department of Radiation Oncology, Amsterdam UMC, location VUMC, Cancer Center
- Philip van Kuiken
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Maria C. Lecca
- Center for Experimental Molecular Medicine (CEMM), Laboratory for Experimental Oncology and Radiobiology (LEXOR), Amsterdam UMC, location AMC, Cancer Center
- Kristiaan J. Lenos
- Center for Experimental Molecular Medicine (CEMM), Laboratory for Experimental Oncology and Radiobiology (LEXOR), Amsterdam UMC, location AMC, Cancer Center
- Sjors G. J. G. In ‘t Veld
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Wessel van Wieringen
- Department of Epidemiology and Biostatistics, Amsterdam UMC, location VUMC
- Frederick F. Lang
- Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center
- Erik Sulman
- Department of Radiation Oncology, NYU Langone Health
- Roel Verhaak
- Department of Computational Biology, The Jackson Laboratory for Genomic Medicine
- Brigitta G. Baumert
- Department of Radio-Oncology, Kantonsspital Graubünden, Loëstrasse 170
- Lucas J. A. Stalpers
- Radiation Oncology, Academic Medical Center
- Louis Vermeulen
- Center for Experimental Molecular Medicine (CEMM), Laboratory for Experimental Oncology and Radiobiology (LEXOR), Amsterdam UMC, location AMC, Cancer Center
- Colin Watts
- Neurosurgery, Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston
- David Bailey
- IOTA Pharmaceuticals Ltd, St Johns Innovation Centre, Cowley Road
- Ben J. Slotman
- Department of Radiation Oncology, Amsterdam UMC, location VUMC, Cancer Center
- Rogier Versteeg
- Department of Oncogenomics, Academic Medical Center
- David Noske
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Peter Sminia
- Department of Radiation Oncology, Amsterdam UMC, location VUMC, Cancer Center
- Bakhos A. Tannous
- Experimental Therapeutics and Molecular Imaging Lab, Neuroscience Center, Neuro-Oncology Unit, Massachusetts General Hospital and Harvard Medical School
- Tom Wurdinger
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- Jan Koster
- Department of Oncogenomics, Academic Medical Center
- Bart A. Westerman
- Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-16735-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for exploring and understanding effective drug combinations.
