Wavelet transform-based photoacoustic time-frequency spectral analysis for bone assessment

Weiya Xie; Ting Feng; Mengjiao Zhang; Jiayan Li; Dean Ta; Liming Cheng; Qian Cheng

Photoacoustics (Jun 2021)

Wavelet transform-based photoacoustic time-frequency spectral analysis for bone assessment

Weiya Xie,
Ting Feng,
Mengjiao Zhang,
Jiayan Li,
Dean Ta,
Liming Cheng,
Qian Cheng

Affiliations

Weiya Xie: Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China; The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, PR China
Ting Feng: Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China; School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, PR China
Mengjiao Zhang: Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China
Jiayan Li: Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China
Dean Ta: Department of Electronic Engineering, Fudan University, Shanghai, PR China
Liming Cheng: The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, PR China; Corresponding authors at: Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China; The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, PR China.
Qian Cheng: Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China; The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, PR China; Corresponding authors at: Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China; The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, PR China.

Journal volume & issue: Vol. 22
p. 100259

Abstract

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In this study, we investigated the feasibility of using photoacoustic time-frequency spectral analysis (PA-TFSA) for evaluating the bone mineral density (BMD) and bone structure. Simulations and ex vivo experiments on bone samples with different BMDs and mean trabecular thickness (MTT) were conducted. All photoacoustic signals were processed using the wavelet transform-based PA-TFSA. The power-weighted mean frequency (PWMF) was evaluated to obtain the main frequency component at different times. The y-intercept, midband-fit, and slope of the linearly fitted curve of the PWMF over time were also quantified. The results show that the osteoporotic bone samples with lower BMD and thinner MTT have higher frequency components and lower acoustic frequency attenuation over time, thus higher y-intercept, midband-fit, and slope. The midband-fit and slope were found to be sensitive to the BMD; therefore, both parameters could be used to distinguish between osteoporotic and normal bones (p < 0.05).

Published in Photoacoustics

ISSN: 2213-5979 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physics: Acoustics. Sound; Science: Physics: Optics. Light
Website: http://www.journals.elsevier.com/photoacoustics/

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