Self-monitored Nd-doped MoSe2 nanosheets with near-infrared luminescent sensing for photothermal therapy

Congcong Wang; Yu Meng; Zewen Su; Junqiang Dong; Yanbang Lian; Youqiang Huang; Yinyan Li; Shiqing Xu; Gongxun Bai

Journal of Materiomics (Jan 2024)

Self-monitored Nd-doped MoSe2 nanosheets with near-infrared luminescent sensing for photothermal therapy

Congcong Wang,
Yu Meng,
Zewen Su,
Junqiang Dong,
Yanbang Lian,
Youqiang Huang,
Yinyan Li,
Shiqing Xu,
Gongxun Bai

Affiliations

Congcong Wang: Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China
Yu Meng: Oncology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China
Zewen Su: Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China
Junqiang Dong: Radiology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China
Yanbang Lian: Radiology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China; Corresponding author.
Youqiang Huang: Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China
Yinyan Li: Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China; Corresponding author.
Shiqing Xu: Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China
Gongxun Bai: Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province, College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China; Corresponding author.

Journal volume & issue: Vol. 10, no. 1
pp. 163 – 172

Abstract

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The acquisition of real-time temperature monitoring during photothermal therapy is significant to prevent unnecessary damage to healthy tissues. However, owing to complexity and diverse factors in microenvironment of cells, there still remain considerable challenges in achieving noninvasive temperature measurement and manipulation in therapeutic process. Herein, biocompatible Nd-doped MoSe2 nanosheets have been developed on the premise of excellent photothermal effect, which manifest desirable photoluminescence and distinct temperature self-monitored capability in near-infrared I and II bio-windows. Based on thermally coupled energy levels of Nd ions, the real-time monitoring on temperature changes in intracellular environment can be realized which provide instant temperature feedbacks to avoid side effects from hyperthermia. Exclusive of detrimental elements such as F and Pb, the objective nanosheets manifest satisfactory biosafety and can induce effective tumor ablation under near-infrared irradiation with photothermal conversion efficiency up to 40.8%, providing an innovative vision for developing more precisely and safely photothermal approaches.

Published in Journal of Materiomics

ISSN: 2352-8478 (Print); 2352-8486 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.sciencedirect.com/journal/journal-of-materiomics

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