Nature Communications (Nov 2022)

Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments

  • Xia Yao,
  • Yan Wang,
  • Zhifei Wang,
  • Xiao Fan,
  • Di Wu,
  • Jian Huang,
  • Alexander Mueller,
  • Sarah Gao,
  • Miaohui Hu,
  • Carol V. Robinson,
  • Yong Yu,
  • Shuai Gao,
  • Nieng Yan

DOI
https://doi.org/10.1038/s41467-022-35026-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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Voltage-gated Ca2+ channel subtype Cav2.3 represents a potential drug target for neurological diseases. Here, authors report cryo-EM structures of Cav2.3 and its mutant to reveal the crosstalk of intracellular segments, which may facilitate future drug discovery.