Frontiers in Nutrition (May 2024)

Healthy Japanese dietary pattern is associated with slower biological aging in older men: WASEDA’S health study

  • Takuji Kawamura,
  • Takuji Kawamura,
  • Mitsuru Higuchi,
  • Tomoko Ito,
  • Tomoko Ito,
  • Ryoko Kawakami,
  • Ryoko Kawakami,
  • Chiyoko Usui,
  • Chiyoko Usui,
  • Kristen M. McGreevy,
  • Steve Horvath,
  • Steve Horvath,
  • Steve Horvath,
  • Radak Zsolt,
  • Radak Zsolt,
  • Suguru Torii,
  • Katsuhiko Suzuki,
  • Kaori Ishii,
  • Shizuo Sakamoto,
  • Shizuo Sakamoto,
  • Koichiro Oka,
  • Isao Muraoka,
  • Kumpei Tanisawa

DOI
https://doi.org/10.3389/fnut.2024.1373806
Journal volume & issue
Vol. 11

Abstract

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Aging is the greatest risk factor for numerous diseases and mortality, and establishing geroprotective interventions targeting aging is required. Previous studies have suggested that healthy dietary patterns, such as the Mediterranean diet, are associated with delayed biological aging; however, these associations depend on nationality and sex. Therefore, this study aimed to investigate the relationship between dietary patterns identified through principal component analysis and biological aging in older men of Japan, one of the countries with the longest life expectancies. Principal component analysis identified two dietary patterns: a healthy Japanese dietary pattern and a Western-style dietary pattern. Eight epigenetic clocks, some of the most accurate aging biomarkers, were identified using DNA methylation data from whole-blood samples. Correlation analyses revealed that healthy Japanese dietary patterns were significantly negatively or positively correlated with multiple epigenetic age accelerations (AgeAccel), including AgeAccelGrim, FitAgeAccel, and age-adjusted DNAm-based telomere length (DNAmTLAdjAge). Conversely, the Western-style dietary pattern was observed not to correlate significantly with any of the examined AgeAccels or age-adjusted values. After adjusting for covariates, the healthy Japanese dietary pattern remained significantly positively correlated with DNAmTLAdjAge. Regression analysis showed that healthy Japanese dietary pattern contributed less to epigenetic age acceleration than smoking status. These findings suggest that a Western-style dietary pattern may not be associated with biological aging, whereas a healthy Japanese dietary pattern is associated with delayed biological aging in older Japanese men. Our findings provide evidence that healthy dietary patterns may have mild beneficial effects on delayed biological aging in older Japanese men.

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