Bioactive Compounds from Andean Berry (<i>Vaccinium meridionale</i> Swartz) Juice Inhibited Cell Viability and Proliferation from SW480 and SW620 Human Colon Adenocarcinoma Cells

Abstract

The Andean berry is a South American fruit displaying anti-cancer effects. This research aimed to assess the antiproliferative effects of the juice (ABJ) on two human colon cells (SW480/SW620) through viability, proliferation, and Ki67 protein quantification. All treatments (0–30% v/v) reduced viability (50-SW480: 28.19% v/v ABJ; IC50-SW620: 19.43% v/v ABJ). All ABJ-treated cells showed a reduced ki67 amount compared to untreated cells. The highest binding affinity (−9.4 kcal/mol) was shown between cyanidin-3-glucoside and caspase 8 in silico. ABJ exerts antiproliferative/inhibitory effects on SW480/SW620 cells, attributable to polyphenol-apoptotic target interactions.

Keywords

• Andean berry (<i>Vaccinium meridionale</i> Swartz)
• cell viability
• colorectal cancer
• phenolic compounds
• in silico analysis