Crystal structure of 5-(1-benzofuran-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1,2-oxazol-5-ol

Abstract

In the title compound, C18H15NO3, the isoxazole moiety adopts a shallow envelope conformation, with the C atom bearing the OH group displaced by 0.148 (1) Å from the mean plane through the other four atoms. The mean plane of this ring (all atoms) subtends dihedral angles of 87.19 (6) and 15.51 (7)° with the benzofuran ring system (r.m.s. deviation = 0.007 Å) and the 4-methylphenyl ring, respectively. In the crystal, molecules are linked by O—H...N hydrogen bonds, generating [001] C(5) chains, with adjacent molecules in the chain related by c-glide symmetry. Weak C—H...O interactions link the chains into a three-dimensional network.

Keywords

• crystal structure
• benzofuran
• 1,2-oxazole
• alcohol
• biological properties
• pharmaceutical properties