Nature Communications (Sep 2018)
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
- R. Kumar,
- L. Coronel,
- B. Somalanka,
- A. Raju,
- O. A. Aning,
- O. An,
- Y. S. Ho,
- S. Chen,
- S. Y. Mak,
- P. Y. Hor,
- H. Yang,
- M. Lakshmanan,
- H. Itoh,
- S. Y. Tan,
- Y. K. Lim,
- A. P. C. Wong,
- S. H. Chew,
- T. H. Huynh,
- B. C. Goh,
- C. Y. Lim,
- V. Tergaonkar,
- C. F. Cheok
Affiliations
- R. Kumar
- IFOM-p53Lab Joint Research Laboratory, IFOM
- L. Coronel
- IFOM-p53Lab Joint Research Laboratory, IFOM
- B. Somalanka
- p53 Laboratory, Agency for Science Technology and Research
- A. Raju
- Institute of Molecular and Cell Biology, Agency for Science Technology and Research
- O. A. Aning
- Institute of Molecular and Cell Biology, Agency for Science Technology and Research
- O. An
- Cancer Science Institute of Singapore, National University of Singapore
- Y. S. Ho
- Bioprocessing Technology Institute, Agency for Science Technology and Research
- S. Chen
- Bioprocessing Technology Institute, Agency for Science Technology and Research
- S. Y. Mak
- Bioprocessing Technology Institute, Agency for Science Technology and Research
- P. Y. Hor
- p53 Laboratory, Agency for Science Technology and Research
- H. Yang
- Cancer Science Institute of Singapore, National University of Singapore
- M. Lakshmanan
- Institute of Molecular and Cell Biology, Agency for Science Technology and Research
- H. Itoh
- Skin Research Institute of Singapore, Agency for Science Technology and Research
- S. Y. Tan
- Institute of Molecular and Cell Biology, Agency for Science Technology and Research
- Y. K. Lim
- Department of Gynaecological Oncology, KK Women’s and Children’s Hospital
- A. P. C. Wong
- Department of Pathology and Laboratory Medicine, KK Women’s and Children’s Hospital
- S. H. Chew
- Department of Pathology and Laboratory Medicine, KK Women’s and Children’s Hospital
- T. H. Huynh
- Laboratory of Molecular Endocrinology, National Cancer Centre Singapore
- B. C. Goh
- Cancer Science Institute of Singapore, National University of Singapore
- C. Y. Lim
- Skin Research Institute of Singapore, Agency for Science Technology and Research
- V. Tergaonkar
- Institute of Molecular and Cell Biology, Agency for Science Technology and Research
- C. F. Cheok
- IFOM-p53Lab Joint Research Laboratory, IFOM
- DOI
- https://doi.org/10.1038/s41467-018-05805-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Several challenges are involved in direct targeting of mutant p53, while targeting altered fitness of cells with loss of wild type p53 is an alternative approach. Here they identify niclosamide to be selectively toxic to p53 deficient cells through a previously unknown mitochondrial uncoupling mechanism.
