Bacterial Cellulose-Based Materials as Dressings for Wound Healing
Manuel Horue,
Jhonatan Miguel Silva,
Ignacio Rivero Berti,
Larissa Reis Brandão,
Hernane da Silva Barud,
Guillermo R. Castro
Affiliations
Manuel Horue
Laboratorio de Nanobiomateriales, CINDEFI, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP)-CONICET (CCT La Plata), Calle 47 y 115, La Plata B1900, Argentina
Jhonatan Miguel Silva
Biopolymers and Biomaterials Laboratory—BioPolMat, University of Araraquara—UNIARA, Araraquara 14801-320, SP, Brazil
Ignacio Rivero Berti
Laboratorio de Nanobiomateriales, CINDEFI, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP)-CONICET (CCT La Plata), Calle 47 y 115, La Plata B1900, Argentina
Larissa Reis Brandão
Biopolymers and Biomaterials Laboratory—BioPolMat, University of Araraquara—UNIARA, Araraquara 14801-320, SP, Brazil
Hernane da Silva Barud
Biopolymers and Biomaterials Laboratory—BioPolMat, University of Araraquara—UNIARA, Araraquara 14801-320, SP, Brazil
Guillermo R. Castro
Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC), Partner Laboratory of the Max Planck Institute for Biophysical Chemistry (MPIbpC, MPG), Centro de Estudios Interdisciplinarios (CEI), Universidad Nacional de Rosario, Maipú 1065, Rosario S2000, Argentina
Bacterial cellulose (BC) is produced by several microorganisms as extracellular structures and can be modified by various physicochemical and biological strategies to produce different cellulosic formats. The main advantages of BC for biomedical applications can be summarized thus: easy moldability, purification, and scalability; high biocompatibility; and straightforward tailoring. The presence of a high amount of free hydroxyl residues, linked with water and nanoporous morphology, makes BC polymer an ideal candidate for wound healing. In this frame, acute and chronic wounds, associated with prevalent pathologies, were addressed to find adequate therapeutic strategies. Hence, the main characteristics of different BC structures—such as membranes and films, fibrous and spheroidal, nanocrystals and nanofibers, and different BC blends, as well as recent advances in BC composites with alginate, collagen, chitosan, silk sericin, and some miscellaneous blends—are reported in detail. Moreover, the development of novel antimicrobial BC and drug delivery systems are discussed.
