Abstract PET imaging has been, and continues to be, an evolving diagnostic technology. In recent years, the modernizing digital landscape has opened new opportunities for data-driven innovation. One such facet has been data-driven motion correction (DDMC) in PET. As both research and industry propel this technology forward, we can recognize prospects and opportunities for further development. The concept of clinical practicality is supported by DDMC approaches—it is what sets them apart from traditional hardware-driven motion correction strategies that have largely not gained acceptance in routine diagnostic PET; the ease of use of DDMC may help propel acceptance of motion correction solutions in clinical practice. As we reflect on the present field, we should consider that DDMC can be made even more practical, and likely more impactful, if further developed to fit within a real-time acquisition framework. This vision for development is not new, but has been made more feasible with contemporary electronics, and has begun to be revisited in contemporary literature. The opportunities for development lie on a new forefront of innovation where medical physics integrates with engineering, data science, and modern computing capacities. Real-time DDMC is a systems integration challenge, and achieving it will require cooperation between hardware and software developers, and likely academia and industry. While challenges for development do exist, it is likely that we will see real-time DDMC come to fruition in the coming years. This effort may establish groundwork for developing similar innovations in the emerging digital innovation age.