EFFICACY OF COMBINED TREATMENT OF JUVENILE ARTHRITIS WITH IBUPROFEN IN DIFFERENT ROUTE OF INTRODUCTION

Abstract

The objective of trial was to investigate the efficacy of oral dosing ibuprofen (Nurofen) in monotherapy or combined with local application of ibuprofen in gel in patients with juvenile arthritis (JRA). Distinct antibinflammatory and analgesic action was caused by ibuprofen 35–40 mg/kg in patients with mono and oligoarthritis with moderate degree of activity of pathologic process in first two weeks of treatment. The combination of oral dosing ibuprofen and its local application in gel prolongs the activity of drug, hastens the regression of swelling in the joints area; therapeutic action begins more rapidly. Ibuprofen was well tolerated. Adverse events leading to the drug withdrawal were in 6% of patients, they were more frequent in first days of treatment. Different forms of ibuprofen are recommended as initial treatment of juvenile arthritis.Key words: children, juvenile arthritis, ibuprofen, management.