Program in Developmental Biology, Baylor College of Medicine, Houston, United States; Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, United States
William Tin-Shing Choi
Program in Developmental Biology, Baylor College of Medicine, Houston, United States; Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, United States; Medical Scientist Training Program, Baylor College of Medicine, Houston, United States
Aleksandar Bajic
Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, United States; Department of Pediatrics, Baylor College of Medicine, Houston, United States
Aarohi Thakkar
Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, United States; Department of Pediatrics, Baylor College of Medicine, Houston, United States
Juan Manuel Encinas
Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, United States; Achucarro Basque Center for Neuroscience and Ikerbasque, The Basque Science Foundation, Bizkaia, Spain
Frederic Depreux
Department of Cell Biology and Anatomy, Rosalind Franklin University of Medicine and Science, Chicago, United States
Neil Segil
Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, United States; Caruso Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, United States
Program in Developmental Biology, Baylor College of Medicine, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Department of Neuroscience, Baylor College of Medicine, Houston, United States
Program in Developmental Biology, Baylor College of Medicine, Houston, United States; Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, United States; Department of Pediatrics, Baylor College of Medicine, Houston, United States; Department of Neuroscience, Baylor College of Medicine, Houston, United States
Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor, is selectively expressed in NSCs. Further, Lfng in NSCs and Notch ligands Delta1 and Jagged1, expressed by their progeny, together influence NSC recruitment, cell cycle duration, and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the ‘mother’ cell to modify its cell cycle status. Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.
