The SWGEDWGEIW from Soybean Peptides Reduce Oxidative Damage-Mediated Apoptosis in PC-12 Cells by Activating SIRT3/FOXO3a Signaling Pathway
Guofu Yi,
Mengyue Zhou,
Qingfei Du,
Shuibing Yang,
Yuxia Zhu,
Yining Dong,
Yang Liu,
He Li,
You Li,
Xinqi Liu
Affiliations
Guofu Yi
College of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China
Mengyue Zhou
College of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China
Qingfei Du
College of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China
Shuibing Yang
College of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China
Yuxia Zhu
College of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China
Yining Dong
College of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China
Yang Liu
College of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China
He Li
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China
You Li
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China
Xinqi Liu
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China
The goal of the investigation was to study the protective effects of the SWGEDWGEIW (the single peptide, TSP) from soybean peptides (SBP) on hydrogen peroxide (H2O2)-induced apoptosis together with mitochondrial dysfunction in PC-12 cells and their possible implications to protection mechanism. Meanwhile, the SBP was used as a control experiment. The results suggested that SBP and TSP significantly (p p < 0.05) raised the SIRT3 protein expression and the downstream functional gene FOXO3a. In the above activity tests, the activity of TSP was slightly higher than that of SBP. Taken together, our findings suggested that SBP and TSP can be used as promising nutrients for oxidative damage reduction in neurons, and TSP is more effective than SBP. Therefore, TSP has the potential to replace SBP and reduce neuronal oxidative damage.
