PLoS ONE (Jan 2012)

Connection between genetic and clinical data in bipolar disorder.

  • Erling Mellerup,
  • Ole Andreassen,
  • Bente Bennike,
  • Henrik Dam,
  • Srdjan Djurovic,
  • Thomas Hansen,
  • Ingrid Melle,
  • Gert Lykke Møller,
  • Ole Mors,
  • Pernille Koefoed

DOI
https://doi.org/10.1371/journal.pone.0044623
Journal volume & issue
Vol. 7, no. 9
p. e44623

Abstract

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Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data.