BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens

André O. White; Enikö A. Kramár; Alberto J. López; Janine L. Kwapis; John Doan; David Saldana; M. Felicia Davatolhagh; Yasaman Alaghband; Mathew Blurton-Jones; Dina P. Matheos; Marcelo A. Wood

doi:10.1038/ncomms11725

Nature Communications (May 2016)

BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens

André O. White,
Enikö A. Kramár,
Alberto J. López,
Janine L. Kwapis,
John Doan,
David Saldana,
M. Felicia Davatolhagh,
Yasaman Alaghband,
Mathew Blurton-Jones,
Dina P. Matheos,
Marcelo A. Wood

Affiliations

André O. White: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
Enikö A. Kramár: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
Alberto J. López: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
Janine L. Kwapis: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
John Doan: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
David Saldana: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
M. Felicia Davatolhagh: Perelman School of Medicine at the University of Pennsylvania
Yasaman Alaghband: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
Mathew Blurton-Jones: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
Dina P. Matheos: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California
Marcelo A. Wood: Department of Neurobiology and Behavior, 301 Qureshey Research Lab, University of California

DOI: https://doi.org/10.1038/ncomms11725
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Epigenetic mechanisms play a key role in drug-associated memories and behaviors. Here authors show that mice deficient of BAF53b, a nucleosome remodeling complex subunit, display deficits in synaptic plasticity and cocaine-associated memory, both of which can be rescued by BDNF application.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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