COMPARATIVE ANALYSIS OF C-REACTIVE PROTEIN AND RED BLOOD CELLS DISTRIBUTION WIDTH LEVELS IN SUBGROUPS DEPENDING ON THE SEVERITY OF HYPERLIPIDEMIA ACCORDING TO LABORATORY REGISTRY DATA

Abstract

Objective: To identify patients with severe hyperlipidemia and to analyze red cells distribution width (RDW) and C-reactive protein (CRP) levels in subgroups depending on the severity of hyperlipidemia. Methods: All patients who underwent complete blood count, total cholesterol (TC) and LDL tests in our hospital from January to December 2016 were included in the study. CRP data were added to the database, if available. Criteria for severe hyperlipidemia were accepted LDL values of 5.0 mmol/L and more in this study. Results: 8056 patient records were included in the final analysis. Detection of severe hyperlipidemia in this population by this criteria was 8.0%. A comparative analysis of RDW and CRP depending on the presence of severe hyperlipidemia was carried out for the whole study group and for patients with circulatory system diseases (CSD). Differences in the level of CRP and RDW were obtained depending on the presence of severe hyperlipidemia for both groups of patients. But statistically significant differences were obtained only in RDW level in patients with CSD. Among them, the RDW level in patients with severe hyperlipidemia was lower: 12.9±0.8 (n=173) vs 13.2±0.8 (n=2119), p=0.007. Conclusion: Statistically significant differences were found in the level of RDW in patients with severe hyperlipidemia only in the group of patients with CSD (but not for the whole group). RDW should be considered as an additional biomarker in patients with cardiovascular diseases.

Keywords

• c-reactive protein
• red blood cells distribution width
• ldl
• screening
• severe hyperlipidemia.