Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats

Teppei Goto; Hiromasa Hara; Makoto Sanbo; Hideki Masaki; Hideyuki Sato; Tomoyuki Yamaguchi; Shinichi Hochi; Toshihiro Kobayashi; Hiromitsu Nakauchi; Masumi Hirabayashi

doi:10.1038/s41467-019-08394-9

Nature Communications (Feb 2019)

Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats

Teppei Goto,
Hiromasa Hara,
Makoto Sanbo,
Hideki Masaki,
Hideyuki Sato,
Tomoyuki Yamaguchi,
Shinichi Hochi,
Toshihiro Kobayashi,
Hiromitsu Nakauchi,
Masumi Hirabayashi

Affiliations

Teppei Goto: Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences
Hiromasa Hara: Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences
Makoto Sanbo: Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences
Hideki Masaki: Division of Stem Cell Therapy, Institute of Medical Science, The University of Tokyo
Hideyuki Sato: Division of Stem Cell Therapy, Institute of Medical Science, The University of Tokyo
Tomoyuki Yamaguchi: Division of Stem Cell Therapy, Institute of Medical Science, The University of Tokyo
Shinichi Hochi: Faculty of Textile Science and Technology, Shinshu University
Toshihiro Kobayashi: Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences
Hiromitsu Nakauchi: Division of Stem Cell Therapy, Institute of Medical Science, The University of Tokyo
Masumi Hirabayashi: Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences

DOI: https://doi.org/10.1038/s41467-019-08394-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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The use of pluripotent-stem cell derived organs for transplantation would be promising, if organs can be grown in a suitable host. Here, the authors use interspecific blastocyst complementation to generate a mouse pluripotent stem cell-derived kidney in anephric Sall1 mutant rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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