Haematologica (Oct 2007)

Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines

  • Rafael Henriques Jácomo,
  • Raul Antonio Morais Melo,
  • Fernanda Ribeiro Souto,
  • Éderson Roberto de Mattos,
  • Claudia Teresa de Oliveira,
  • Evandro M. Fagundes,
  • Henrique Neves da Silva Bittencourt,
  • Rosane Isabel Bittencourt,
  • Teresa Cristina Bortolheiro,
  • Eduardo J.A. Paton,
  • Rodrigo Bendlin,
  • Sebastião Ismael,
  • Maria de Lourdes Chauffaille,
  • Dirceu Silva,
  • Katia Borgia B. Pagnano,
  • Raul Ribeiro,
  • Eduardo M. Rego

DOI
https://doi.org/10.3324/haematol.10874
Journal volume & issue
Vol. 92, no. 10

Abstract

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We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).