Journal of Pain Research (Dec 2018)

The efficacy of pregabalin for the management of acute and chronic postoperative pain in thoracotomy: a meta-analysis with trial sequential analysis of randomized-controlled trials

  • Yu Y,
  • Liu N,
  • Zeng Q,
  • Duan J,
  • Bao Q,
  • Lei M,
  • Zhao J,
  • Xie J

Journal volume & issue
Vol. Volume 12
pp. 159 – 170

Abstract

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Yijin Yu,1 Nan Liu,2 Qingxin Zeng,3 Jing Duan,1 Qi Bao,1 Min Lei,1 Jinning Zhao,1 Junran Xie1 1Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China; 2Department of Anesthesiology, Hangzhou Xiasha Hospital, Zhejiang, China; 3Department of Thoracic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China Purpose: Pregabalin is commonly used as an analgesic for neuropathic pain. But pregabalin as an adjunct to a multimodal analgesic regimen – although standard clinical protocol in some settings – has remained controversial. This meta-analysis was conducted to identify the efficacy of pregabalin for management of postoperative pain in thoracotomy.Materials and methods: Pubmed, Embase, Cochrane, Web of Science, Springer, and Clinical Trial Register database were searched for randomized controlled trials (RCTs) of pregabalin in preventing postoperative pain in thoracotomy. Review Manager 5.3 and STATA 12.0 were selected to conduct the meta-analysis. Trial sequential analysis was used to control random errors and calculate the required information size.Results: Nine RCTs with 684 patients were included in our meta-analysis. Outcomes favoring pregabalin included less pain on a 0–10 scale on 1 day [mean difference (MD): –0.87; 95% CI: –1.55 to –0.19; P=0.01], 3 days (MD: –1.55; 95% CI: –1.93 to –1.18; P<0.00001), 1 month (MD: –1.58; 95% CI: –2.75 to –0.42; P=0.008), 3 months (MD: –1.69; 95% CI: –2.71 to –0.66; P=0.001) postoperatively, and less incidence of neuropathic pain (OR: 0.20; 95% CI: 0.05–0.91; P=0.04), less mean morphine consumption (MD: –5.03; 95% CI: –8.06 to –1.99; P=0.001), but more dizziness (OR: 3.33; 95% CI: 1.36–8.17; P=0.009), more drowsiness (OR: 8.61; 95% CI: 2.23–33.20; P=0.002), and less constipation (OR: 0.23; 95% CI: 0.09–0.59; P=0.002). There was no statistical differences in pain score on 7 days (MD:–0.77; 95% CI: –2.38 to 0.84; P=0.35), nausea (OR: 0.73; 95% CI: 0.42–1.26; P=0.26), and vomiting (OR: 0.83; 95% CI: 0.36–1.90; P=0.65).Conclusion: Pregabalin can prevent postoperative pain in thoracotomy and decrease incidence of neuropathic pain and morphine consumption. Pregabalin may be a valuable asset in management of acute and persistent postoperative pain in thoracotomy. Keywords: pregabalin, postoperative pain, thoracotomy, meta-analysis, neuropathic pain

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