Nature Communications (Nov 2019)
Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes
- Yasunobu Nagata,
- Hideki Makishima,
- Cassandra M. Kerr,
- Bartlomiej P. Przychodzen,
- Mai Aly,
- Abhinav Goyal,
- Hassan Awada,
- Mohammad Fahad Asad,
- Teodora Kuzmanovic,
- Hiromichi Suzuki,
- Tetsuichi Yoshizato,
- Kenichi Yoshida,
- Kenichi Chiba,
- Hiroko Tanaka,
- Yuichi Shiraishi,
- Satoru Miyano,
- Sudipto Mukherjee,
- Thomas LaFramboise,
- Aziz Nazha,
- Mikkael A. Sekeres,
- Tomas Radivoyevitch,
- Torsten Haferlach,
- Seishi Ogawa,
- Jaroslaw P. Maciejewski
Affiliations
- Yasunobu Nagata
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Hideki Makishima
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Cassandra M. Kerr
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Bartlomiej P. Przychodzen
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Mai Aly
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Abhinav Goyal
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Hassan Awada
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Mohammad Fahad Asad
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Teodora Kuzmanovic
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Hiromichi Suzuki
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Tetsuichi Yoshizato
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Kenichi Yoshida
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Kenichi Chiba
- Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Hiroko Tanaka
- Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Yuichi Shiraishi
- Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Satoru Miyano
- Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Sudipto Mukherjee
- Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic
- Thomas LaFramboise
- Department ofGenetics and Genome Sciences, Case Western Reserve University
- Aziz Nazha
- Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic
- Mikkael A. Sekeres
- Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic
- Tomas Radivoyevitch
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Torsten Haferlach
- MLL Munich Leukemia Laboratory
- Seishi Ogawa
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Jaroslaw P. Maciejewski
- Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- DOI
- https://doi.org/10.1038/s41467-019-13001-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Stepwise acquisition of mutations gives rise to myelodysplastic syndrome (MDS) in older adults. Here, the authors infer the clonal hierarchy of 1809 MDS patients, revealing insights into the evolution of dominant/secondary mutations and how these impact clinical phenotypes like leukemic progression and therapy response.
